95 Table 8. Changes in Median Survival of MBC Over Time, According to Study Authors, Year Population Database Time Frame Median Survival Change over Time Dawood et al. 2008 [103] >15,000 de novo MBC NCI SEER Registries, US 1988– 2003 • Increase from 20 months to 27 months among non-Hispanic white women • No change (from 17 months) among black women Chia et al. 2007 [104] 2150 MBC patients British Columbia Cancer Agency, Canada 1991– 2001 Increase from 14 months to 22 months Giordano et al. 2004[105] 834 patients with recurrent MBC* MD Anderson Cancer Center, US 1974– 2000 Increase from 15 months to 58 months Ruiterkamp et al. 2011 [106] 8000 patients with de novo MBC Netherlands Cancer Registry 1995– 2008 Increase from 17 months to 23 months Ernst et al. 2007 [107] 1089 patients with de novo MBC South-East Netherlands Registry 1975– 2002 Increase from 18 months to 21 months Andre et al. 2004 [108] 724 patients with de novo MBC 3 French cancer centers 1987– 2000 Increase from 23 to 29 months overall • Increase from 28 months to 45 months among patients with ER+ MBC • No change among those with ER− MBC Abbreviations: ER = estrogen receptor, MBC = metastatic breast cancer, NCI = National Cancer Institute, SEER = Surveillance, Epidemiology, and End Results program, US = United States. * Sample included patients with locally advanced relapse.