Appendix 4: Examples of How Grants in the MBC Grants Dataset Were Further Categorized into the Metastasis Stage Molecular pathways and targets (CY 2000 - 2013) Includes any awards active over this thirteen year period Awards are categorized into Basic, Translational or Clinical, based on their CSO profile Where possible, pathways/targets have been grouped into categories Basic research awards Translational research awards Clinical research awards Pathway (Group) Total Molecular Target (Group) Total Molecular Target (Group) Total Other 22.0% Other 23.4% Other 24% Multiple 12.5% 0_No specific target 16.4% 0_No specific target 17% Bone/osteolysis pathways 6.7% Multiple 7.4% Multiple 11% Pathway not specified 4.9% Integrins, Cadherins etc. 3.9% Erb/Her 6% Angiogenic pathways 4.6% Erb/Her 3.1% hormone receptors 5% Integrins, Cadherins etc. 3.4% cytokines and chemokines 3.0% VEGF pathway family 3% TGF 3.3% Bone/osteolysis pathways 2.7% (blank) 3% cytokines and chemokines 2.9% Stem cells 2.5% IGF signalling 3% Stem cells 1.8% TGF 2.1% Bone/osteolysis pathways 3% Hypoxia factors 1.5% matrix metalloproteinases 2.0% HGF/MET 2% matrix metalloproteinases 1.5% VEGF pathway family 1.8% urokinase (uPA-R) pathway 2% Rho family GTPases 1.4% (blank) 1.8% angiogenesis factor 2% VEGF pathway family 1.4% angiogenesis factor 1.7% Immune system (general) 2% Erb/Her 1.4% Circulating tumour cells (CTC) 1.4% thymidylate synthase 2% Immune system (general) 1.3% Hypoxia factors 1.4% p53 pathway 2% Src + family 1.0% NF Kappa B pathway 1.2% Integrins, Cadherins etc. 1% NF Kappa B pathway 1.0% hormone receptors 1.0% Src + family 1% hormone receptors 1.0% Interleukins 0.9% cytokines and chemokines 1% microRNAs (miRNAs) 1.0% urokinase (uPA-R) pathway 0.9% COX 1% Six family genes 0.8% Immune system (general) 0.9% Stem cells 1% FAK 0.8% EGF pathway 0.8% HSP 1% Twist 0.8% cysteine proteases 0.8% TGF 1% STAT 0.7% tumor necrosis family (TNF) superfamily 0.8% Ras pathway 1% receptor tyrosine kinase 0.6% Fibroblast activation protein (FAP) 0.7% PI3 kinase 1% Cell surface glycoproteins 0.6% IGF signalling 0.7% disintegrin family 1% cytoskeleton 0.6% COX 0.7% breast tumor suppressors 1% Protein kinases 0.5% Ephrins 0.7% Circulating tumour cells (CTC) 1% Ras pathway 0.5% HSP 0.6% MUC1 0% HGF/MET 0.5% NK cells 0.6% matrix metalloproteinases 0% Collagen 0.5% p38 pathway 0.5% minor fatty acids 0% MUC1 0.5% Galectins 0.5% ID-2/ID-1 0% stress pathways 0.5% Rho family GTPases 0.5% tumor necrosis family (TNF) super- family 0% FGF signalling 0.5% Cell surface glycoproteins 0.5% Rho family GTPases 0% brain metastases 0.5% ID-2/ID-1 0.4% FGF signalling 0% Ephrins 0.4% MUC1 0.4% Fibroblast activation protein (FAP) 0% Wnt signalling 0.4% AKT PKB signalling 0.4% prolactin (PRL) 0% insulin receptor substrate (IRS) 0.4% FAK 0.4% transcription factor 0% metastasis suppressor genes 0.4% PTHrP 0.4% proteases 0%