BMN 673 PARP BRCA+ National Cancer Institute AZD2281 (olaparib) PARP BRCA+ Carboplatin National Cancer Institute AZD2281 (olaparib) PARP All With/without carbo- platin National Cancer Institute Rucaparib  PARP BRCA+ Clovis Oncology Niraparib PARP HER2- TESARO HDAC Inhibitors Vorinostat HDAC Unknown as of 8/1 Vorinostat HDAC All Capecitabine Yale Cancer Center/Merck Vorinostat  HDAC All Paclitaxel, carboplatin National Cancer Institute Etinostat HDAC HER2+ Lapatinib National Cancer Institute/MD Anderson Cancer Center Romidepsin HDAC Protein-bound pacli- taxel Thomas Jefferson University/ Celgene Romidepsin HDAC All National Cancer Institute Entinostat  HDAC Hormone+_HER2- Exemestane  National Cancer Institute Entinostat  HDAC Hormone+_HER2- Exemestane  National Cancer Institute Other PM01183 Minor groove of DNA BRCA+ PharmaMar Subtotal 7. Tumor Promoting Inflammation NOT IN TRIALS FOR MBC 8. Deregulating Cel- lular Energetics NOT IN TRIALS FOR MBC 9. Activating Invasion and Metastasis Fresolimumab (GC1008) TGF-Beta All Radiotherapy New York University 10. Avoiding Immune Destruction Vaccines AntiHER2/antiCD3-acti- vated T Cells HER2, CD3 HER2- Cyclophophamide AdHER2/neu dendritic cell vaccine ERB2 HER2+ National Cancer Institute HER2 peptide-based Vaccine ERB2 HER2+ University of Washington Dendritic cell vaccine with oncofetal antigen/ iLRP Tumor antigen OFA/iLRP All Southern Cancer Center Designer T cells CEA CEA+ Roger Williams Medical Center HER2neu DNA Vaccine ERB2 HER2+ Sloan Kettering HER2 ICD Peptide Vac- cine ERB2 HER2+ Trastuzumab/ polysaccharide-K University of Washington Active, not recruiting Mammaglobin-A DNA Vaccine Mammaglobin- A All Washington University, St. Louis ONT-10 MUC1 All Oncothyreon cMet RNA chimeric antigen receptor (CAR) T cells Tumor anti- gens All Abramson Cancer Center, University of Pennsylvania FANG vaccine (bi- shRNAfurin and GMCSF autologous tumor cells) Tumor anti- gens All Gradalis, Inc. OPT-822/OPT-821 Globo H All cyclophosphamide OBI Pharma, Inc. hTERT/survivin multi- peptide vaccine hTERT All basiliximab, GM-CSF and Prevnar Abramson Cancer Center, University of Pennsylvania Study Drug(s) Target Biomarkers/ Subtype Combination Sponsor