67 is an important component of self-efficacy, enabling patients to regain a sense of control. In 1 survey, feeling informed was statistically associated with lower levels of anxiety, depression, and fatigue as patients reported a greater sense of control, despite uncertainty[3] . At least three quarters of surveyed patients say they seek information about MBC and treatment options “very frequently”[3, 59] , a finding confirmed in face-to-face interviews with a broader, international patient population[60] . Information on coping with and managing side effects and symptoms is also strongly desired by most patients. Almost all MBC patients surveyed say that being informed about treatments and the progression of disease helps their quality of life[61] . Nearly half of MBC patients surveyed say they find the information they need difficult to locate and confusing and that what they do find does not fully address their needs. In fact, informational needs of patients change throughout the course of MBC. There are significant times when patients and family members seek information from HCPs and elsewhere: initial MBC diagnosis, treatment failure, symptom crisis, disease progression, and end of life. Patients also vary in their response to the information formats available—websites and webinars, teleconferences, videos, print materials, meetings, presentations, and conferences. Thus, information is probably best delivered in several of these formats. In addition, the type of information sought varies. For example, young MBC patients express concerns related to genetic testing, fertility, dating, children, career, and other issues and want resources and support dedicated to their specific needs[59] . In addition, information and support are not distinct from one another. MBC patients find information to be supportive and seek information from their support systems; thus, services for MBC patients should offer both[3] . Access to information is not only associated with patients’ ability to cope but also affects clinical trial enrollment. Surveys show that MBC patients who seek out information are more likely than others to participate in clinical trials[60, 61] . Patients are often motivated to participate in trials because they believe that access to new treatments is vital to extending life; treatment choices may be limited by cost, insurance coverage, and delays in trial completion. However, patients say they are rarely informed about new treatments or clinical trials available and even more rarely about those beyond their hospital or oncology practice[61] . When they do enroll in clinical trials, MBC patients most commonly cite encouragement from their HCPs as the reason for their participation[75] . Informationis perceivedas a primary need by about 75%of MBC patients. Feeling informed is associated with lower levels of anxiety, depression, and fatigue as patients reported a greater sense of control, despite uncertainty.