ATYPICAL RESPONDERS LANDSCAPE REVIEW ∙ OCTOBER, 2017 36 ESTABLISH A NEW TEST, ASSAY, SURVEY, ETC. OR UTILIZE ONE THAT IS ALREADY AVAILABLE THAT PREDICTS THE REASON FOR THE ATYPICAL RESPONSE. CONSIDER OTHER POTENTIAL CONFOUNDING FACTORS AND UPDATE THE DATABASE ACCORDINGLY. FIGURE 1 OVERVIEW OF ATYPICAL RESPONSE ANALYSES AND RELATED CLINICAL OUTCOMES IDENTIFY ATYPICAL RESPONSE. THESE DE-IDENTIFIED DATA CAN BE STORED IN A CENTRAL DATABASE. BY PERFORMING MOLECULAR TESTING OF THE TUMOR OR NORMAL TISSUE BY DETERMINING AN ASSOCIATION BETWEEN A LIFESTYLE OR OTHER FACTOR AND THE RESPONSE DETERMINE THE REASON FOR THE ATYPICAL RESPONSE BY CONDUCTING RIGOROUS SCIENTIFIC AND CLINICAL STUDIES TO COLLECT EVIDENCE FOR A GENOTYPE/ PHENOTYPE/OUTCOME LINK BY CONDUCTING RIGOROUS SCIENTIFIC AND CLINICAL STUDIES TO COLLECT EVIDENCE FOR A LINK BETWEEN LIFESTYLE OR OTHER FACTOR AND CLINICAL OUTCOME PROVIDE MULTI-FACTORIAL CRITERIA FOR PHYSICIANS TO A PRIORI SELECT THE BEST THERAPEUTIC REGIMEN FOR AN INDIVIDUAL PATIENT AND AVOID THOSE LIKELY TO RESULT IN A POOR OUTCOME. IMPROVED CLINICAL OUTCOMES AND QUALITY OF LIFE