Developed by Khawai.

This chart shows ongoing metastatic breast cancer clinical trials that were recruiting patients as of August, 2018.
These charts are intended to aid the MBC Alliance in tracking metastatic clinical trials. For people searching for MBC trials, review Metastatic Trial Search
and consider signing up for trial alerts at BreastCancerTrials.org.

  • Click on a tab to separate the listed trials by various parameters.
  • Hover over a bubble to learn more about that trial.
  • Click on a bubble for more information on that trial as reported by breastcancertrials.org.
  • Click on a "Legend" button at the bottom of the chart to change the color legend and reveal new patterns!

All Trials By Phase By Compound By Breast Cancer Subtype By Hallmarks of Cancer By Line of Therapy By Sponsor
Phase legend Subtype legend Sponsor legend

Methods

We obtained clinical trial data from ClinicalTrials.gov and BreastCancerTrials.org through August 2018.

Inclusion criteria:

  • We focused on trials of all phases enrolling patients with metastatic breast cancer.
  • We primarily included trials investigating one or more chemotherapy, targeted therapies and/or immunomodulatory agents.

Exclusion criteria:

  • We excluded trials that only enrolled patients with early-stage breast cancer
  • We excluded surveys and lifestyle-only, surgery-only, and radiation-only interventions

Note: We excluded 4 "mega-trials" from the data visualization:
  • The trial "The Health of Women Study (HOW)" (NCT02334085) will include 100,000 patients with a study end date in 2031
  • The trial "A Breast Cancer Information Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer (BCCR)" (NCT00666731) will include 999,999 patients with a study end date in 2031
  • The trial "Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program" (NCT01772771) will include 8000 patients with a study end date in 2032
  • The trial "NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma" (NCT02465060) will include 3000 patients with a study end date in 2022
Considering that the size of each bubble is a function of the number of patients in the trial, displaying these mega-trials would distort the reading and the analysis of the graphic.

About Bubble charts

A bubble chart typically displays data triplets (x, y, z) corresponding to three continuous variables: x and y to define the position, and z, the radius of each bubble. In our example, x and y coordinates are optimized according to an algorithm which essentially balances bubble's gravity (i.e. action of moving towards the center of the plot), friction (i.e. velocity decay), and charge (or repulsion/attraction force). This layout is frequently used for network visualization. In addition to x, y and z, it is possible to encode other information. For instance, the color coding informs us about the category of sponsor for each trial, while each tab provides a different view of what the trials breakdown looks like. So, the current webpage displays data from 297 clinical trials, in 21 different ways.

Data source

Data source: click here to download the database (excel format)